Run To The Future

On 64 bit Snow Leopard (Mac OSX) in particular, get the latest version of MySQLdb for Python.

You will then need to make sure you have a 64 bit version of MySQL installed (I installed it from source), and that the /usr/local/src/MySQL-python-1.2.3c1/setup_posix.py file (this is the particular version I have) is using the correct mysql_config. Either make sure your PATH is correct or edit that file (suggested here).

Of course you also need to have the 64 bit version of python installed.

Frustrated users should also read this (note how accurate the article title is).